Drug may help treat muscular dystrophy
BALTIMORE, Oct. 4 (UPI) -- Baltimore researchers have
found that an old, cheap, widely prescribed
blood-pressure medication helps stop muscle wasting in
muscular dystrophy.
Johns Hopkins researchers say the blood-pressure
medication losartan, or Cozaar, stops muscle wasting in
mice carrying the genetic mutation for the most common,
or Duchenne form, of muscular dystrophy.
After treating the mice for six months the scientists
tested the animals' muscle strength by giving them
objects to hold onto. Treatment with losartan
successfully led to significantly increased strength and
decreased muscle fatigue when compared to untreated
littermates.
The researchers have shown that muscle destruction
seen in Duchenne muscular dystrophy and Marfan syndrome
is due to stem cells in the muscle being unable to
repair damaged muscle cells. These stem cells are unable
to repair muscle damage because floating around the body
there is too much of a certain protein, known as
TGF-beta, or transforming growth factor beta.
"This really is the first evidence that disrupting
TGF signaling in cases of failed muscle regeneration can
improve muscle repair," says Dr. Ronald Cohn of the
McKusick-Nathans Institute for Genetic Medicine at
Hopkins. "We're excited that targeting the TGF-beta
pathway may lead to new therapies for treating
muscle-wasting diseases and give affected kids new
hope."
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